Plasma level of advanced oxidation protein products as a novel biomarker of acute lung injury following cardiac surgery

This study was designed to test the hypothesis that whether the plasma level of advanced oxidant protein products (AOPPs) would be useful for the clinical diagnosis of acute lung injury (ALI) following cardiac surgery with the technique of cardiopulmonary bypass (CPB). In this prospective study, seventy consecutive adults undergoing open heart surgery with CPB were included and assigned into the ALI (n = 18) and non-ALI (n = 52) groups according to the American-European Consensus Criteria. Plasma concentrations of AOPPs were measured at baseline, postoperative 1 h, 12 h, 24 h, and 48 h. Eighteen patients (25.7 %) developed ALI after surgery. The plasma levels of AOPPs in the ALI group were significantly increased and remained considerably higher at all time points after operation (all P < 0.05). Multivariate logistic regression analysis revealed that the plasma level of AOPPs at 1 h after operation was an independent predictor for the diagnosis of ALI (OR 1.164; 95 % CI 1.068-1.269; P = 0.001). Plasma level of AOPPs could serve as an early biomarker of the incidence of ALI in adult patients who underwent open cardiac surgery with the technique of CPB.